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Science

Introducing MNC101: Next-generation therapeutics

A superior MANF fragment with neurorestorative abilities and unique features

MyNeuroCure is focused on developing ground-breaking medical therapies to halt the progression of ALS and other neurological diseases. We have discovered novel fragments of naturally occurring proteins that delay symptom onset and reduce motor symptoms of ALS in animals, while reducing pathological events in several cell- and animal models. 

We are committed to developing next-generation therapeutics, and finally meeting the unmet needs in the ALS market. In addition to ALS, we are exploring the potential of our discovery for the treatment of Multiple Sclerosis, Parkinson's Disease, and Diabetes Mellitus.
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Microscope

Discovery

Our science is based on long-term expertise on biology and pharmacology of MANF protein in health and disease. We have identified the critical structural elements behind the therapeutic effects of MANF and developed a novel MNC101 that has similar effects as MANF but it also passes biological barriers such as the blood-brain barrier (BBB). We aim to develop ground-breaking medical therapies to halt the progression of neurological diseases (ALS, MS) and other degenerative diseases (diabetes). We have strong preclinical data in ALS and MS. In preclinical studies of ALS, MANF fragment delays  the symptom onset, reduces motor symptoms and pathological events. 
 
MNC101:

 

  • has a unique, dual mode of action, regulating the UPR, reducing ER-stress (intracellular mode of action) and inhibiting the synthesis and release of pro-inflammatory cytokines (extracellular mode of action). 

  • penetrates the blood-brain-barrier (BBB) and diffuses in the brain tissue. 

  • allows non-invasive treatment immediately after diagnosis due to subcutaneous administration

  • shows no off-target effects or in vivo side-effects â€‹

  • its selectivity has the potential to be easily tailored to target indications beyond ALS to a myriad of neurological diseases with common mechanisms, e.g. MS and Parkinson's disease.​

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discovery
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